Pre_GI Gene

Some Help

Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3923804 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39238043924145342hypothetical proteinBLASTP
39241203924410291hypothetical proteinBLASTP
39244273924888462hypothetical proteinBLASTP
39249093925421513hypothetical proteinBLASTP
392538839267701383hypothetical proteinBLASTP
39276893927847159hypothetical proteinBLASTP
39278443928155312hypothetical proteinBLASTP
39281523928433282hypothetical proteinBLASTP
39288063929738933transcriptional regulatorsQuickGO ontologyBLASTP
39299003930616717hypothetical proteinBLASTP
39308763931178303hypothetical proteinBLASTP
39313933931797405hypothetical proteinBLASTP
39320823932462381hypothetical proteinBLASTP
39331043933241138hypothetical proteinBLASTP
39332383933684447hypothetical proteinBLASTP
393368839351391452hypothetical proteinBLASTP
393513239363641233aspartate aminotransferaseQuickGO ontologyBLASTP
39371303937330201hypothetical proteinBLASTP
39373273937662336hypothetical proteinBLASTP
393767239387211050hypothetical proteinBLASTP
393870539406061902hypothetical proteinBLASTP
394061139421371527hypothetical proteinBLASTP
394220139443842184glycosidaseQuickGO ontologyBLASTP
39423093942512204hypothetical protein
39444353944950516hypothetical proteinBLASTP
39449473945765819inner membrane permease protein of ABC transporterQuickGO ontologyBLASTP
39457653946646882inner membrane permease protein of ABC transporterQuickGO ontologyBLASTP