Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3689000 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
368917336913352163ornithine decarboxylase isozymeQuickGO ontologyBLASTP
36913553691507153hypothetical proteinBLASTP
3692004369207673tRNA-PheQuickGO ontologyBLASTP
36926643693299636hypothetical proteinBLASTP
36939073694275369transposaseQuickGO ontologyBLASTP
36943293694607279transposaseQuickGO ontologyBLASTP
36947003695467768hypothetical proteinBLASTP
369545436977512298hypothetical proteinBLASTP
36977673698402636hypothetical proteinBLASTP
36989343699269336transposaseQuickGO ontologyBLASTP
36990103699267258transposaseQuickGO ontologyBLASTP
36993233699445123transposaseQuickGO ontologyBLASTP
36994793699634156hypothetical protein
37000053700394390hypothetical proteinBLASTP
370050537027272223hypothetical proteinBLASTP
370274237050902349hypothetical proteinBLASTP
370508737077352649proteaseQuickGO ontologyBLASTP
37081533708644492hypothetical proteinBLASTP
37081863708671486hypothetical proteinBLASTP
370864837103841737hypothetical proteinBLASTP
37103843711070687hypothetical proteinBLASTP
371106737124191353hypothetical proteinBLASTP
371243137139751545hypothetical proteinBLASTP
37140183714521504hypothetical proteinBLASTP
37159183716289372hypothetical proteinBLASTP
37167943717189396hypothetical proteinBLASTP
3717402371749796hypothetical proteinBLASTP
37176403718290651hypothetical proteinBLASTP
37194653720115651N-acylhomoserine lactone synthaseQuickGO ontologyBLASTP
37200963720839744transcriptional activatorQuickGO ontologyBLASTP
372140137227771377hypothetical proteinBLASTP