Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3661601 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36616013662422822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
36627103663264555resistance proteinQuickGO ontologyBLASTP
36632493663551303hypothetical proteinBLASTP
36635733664244672deoxyribonucleotide triphosphate pyrophosphataseQuickGO ontologyBLASTP
366422536653671143coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
366555736748899333hypothetical proteinBLASTP
36753883675618231hypothetical proteinBLASTP
36755913676166576hypothetical proteinBLASTP
36762333677159927glutaminaseQuickGO ontologyBLASTP
36772703677596327hypothetical proteinBLASTP
36775963678315720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
367852136797681248adenine glycosylaseQuickGO ontologyBLASTP
36799463680218273hypothetical proteinBLASTP
368038936814771089membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
368176836828771110solute-binding periplasmic protein of ABC transporterQuickGO ontologyBLASTP
368277736850142238TonB-dependent outer membrane receptorQuickGO ontologyBLASTP
368509736861161020permease of ABC transporterQuickGO ontologyBLASTP
368611336876121500ATP-binding component of ABC transport systemQuickGO ontologyBLASTP