Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3505383 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
350429535053861092repressor of galETK operonQuickGO ontologyBLASTP
350538335066451263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
35068153507801987positive regulator for lysQuickGO ontologyBLASTP
350779835089581161MFS transporterQuickGO ontologyBLASTP
35093273510235909transcriptional regulatorQuickGO ontologyBLASTP
351022235112291008hypothetical proteinBLASTP
35113423511977636hypothetical proteinBLASTP
351196335136631701methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
35138093514285477hypothetical proteinBLASTP
35142073514911705hypothetical proteinBLASTP
35151583515307150hypothetical protein
35152073515527321hypothetical proteinBLASTP
35155723516486915type IV prepilin peptidaseQuickGO ontologyBLASTP
35164403516901462hypothetical proteinBLASTP
351689835180881191L-like GSP proteinQuickGO ontologyBLASTP
35180723519028957hypothetical proteinBLASTP
35190373519705669hypothetical proteinBLASTP
35200083520598591hypothetical proteinBLASTP
35205553520992438general protein secretion proteinQuickGO ontologyBLASTP
352101235220581047general protein secretion proteinQuickGO ontologyBLASTP
352220035237111512general secretion proteinQuickGO ontologyBLASTP
352370835256301923general secretion proteinQuickGO ontologyBLASTP
35257113526244534hypothetical proteinBLASTP
35262823526698417hypothetical proteinBLASTP
35274413528196756carbonic anhydraseQuickGO ontologyBLASTP
35285723528880309hypothetical proteinBLASTP
35294833530433951hypothetical proteinBLASTP
353053335327342202hypothetical proteinBLASTP
353280435359173114chondroitin lyaseQuickGO ontologyBLASTP
35362623537044783transposaseIS proteinQuickGO ontologyBLASTP
353704135380631023transposaseQuickGO ontologyBLASTP
35381203538554435transposaseQuickGO ontologyBLASTP
353900635405591554hypothetical proteinBLASTP