Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2966331 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
296633129697533423hypothetical proteinBLASTP
296975029709821233hypothetical proteinBLASTP
29720942972414321transposaseQuickGO ontologyBLASTP
29725452972682138transposaseQuickGO ontologyBLASTP
29731472973617471hypothetical proteinBLASTP
297379029759522163hypothetical proteinBLASTP
29739212974181261hypothetical proteinBLASTP
29759892976249261hypothetical proteinBLASTP
29764032977176774hypothetical proteinBLASTP
297717329794732301hypothetical proteinBLASTP
297948929818372349hypothetical proteinBLASTP
298184029844792640heat shock proteinQuickGO ontologyBLASTP
29848672985358492hypothetical proteinBLASTP
29849002985385486hypothetical proteinBLASTP
298536229870981737hypothetical proteinBLASTP
29870982987784687hypothetical proteinBLASTP
298778129891331353hypothetical proteinBLASTP
298914529906891545hypothetical proteinBLASTP
29907322991235504hypothetical proteinBLASTP
29922212993069849acyl transferaseQuickGO ontologyBLASTP
29934542993942489hypothetical proteinBLASTP
299398129947697893-oxoacyl-acyl carrier protein reductaseQuickGO ontologyBLASTP
29947722995548777enoyl-CoA hydrataseQuickGO ontologyBLASTP
29955262996296771enoyl-coa hydratase proteinQuickGO ontologyBLASTP
299623829974761239hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
299749229982837923-ketoacyl-acyl carrier protein reductaseQuickGO ontologyBLASTP
299823129995141284beta-ketoacyl-acp synthaseQuickGO ontologyBLASTP
29995043000028525myristoyl-acyl carrier dehydrataseQuickGO ontologyBLASTP