Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2937077 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
293707729382521176hypothetical proteinBLASTP
29382982939014717GTP cyclohydrolase IQuickGO ontologyBLASTP
293914429402951152transport proteinQuickGO ontologyBLASTP
29404312941300870transcriptional regulator LYSR-typeQuickGO ontologyBLASTP
294157429427131140alcohol dehydrogenase class III formaldehyde dehydrogenaseQuickGO ontologyBLASTP
29427342943576843esteraseQuickGO ontologyBLASTP
294401229464892478hypothetical proteinBLASTP
294649129477531263hypothetical proteinBLASTP
29477552948423669ATP-binding ABC transporter proteinQuickGO ontologyBLASTP
294843329497431311arylsulfatase activating enzymeQuickGO ontologyBLASTP
295027829515521275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
29515242952324801molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
295246029536681209transposaseQuickGO ontologyBLASTP
29537122954365654hypothetical proteinBLASTP
295459329563561764ATP-binding component of ABC transport systemQuickGO ontologyBLASTP
29568712957494624hypothetical proteinBLASTP
295770629590731368hypothetical proteinBLASTP
29590982959367270hypothetical proteinBLASTP
29593602959551192hypothetical proteinBLASTP
29595512960132582hypothetical proteinBLASTP
296010729611921086hypothetical proteinBLASTP
296115629629191764hypothetical proteinBLASTP