Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2691565 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
26915652692341777transposaseQuickGO ontologyBLASTP
269247326935491077hypothetical proteinBLASTP
26936152693905291hypothetical proteinBLASTP
26938862694158273hypothetical proteinBLASTP
26941892694548360hypothetical proteinBLASTP
26942152694610396hypothetical protein
26945692694844276hypothetical proteinBLASTP
26948612695148288hypothetical proteinBLASTP
26957952696100306hypothetical proteinBLASTP
26965242696664141hypothetical proteinBLASTP
26967482697194447transposaseQuickGO ontologyBLASTP
26972662698225960transposaseQuickGO ontologyBLASTP
26988152699012198hypothetical proteinBLASTP
27001352700260126hypothetical proteinBLASTP
27003492700576228hypothetical proteinBLASTP
2701503270158583tRNA-LeuQuickGO ontologyBLASTP
2701599270166971tRNA-CysQuickGO ontologyBLASTP
2701725270179773tRNA-GlyQuickGO ontology
27019422702490549phosphatidylglycerophosphate synthetaseQuickGO ontologyBLASTP
270254927044021854excinuclease ABC subunit CQuickGO ontologyBLASTP
27043742705030657response regulatorQuickGO ontologyBLASTP
27060422706386345hypothetical proteinBLASTP
27064142706668255hypothetical proteinBLASTP
27070082707559552outer membrane proteinQuickGO ontologyBLASTP
2708249270832173tRNA-LysQuickGO ontology
270867427100981425symporter of D-alanine D-serine and glycineQuickGO ontologyBLASTP
271022427114021179hypothetical proteinBLASTP
27117812712395615TrpR binding protein WrbAQuickGO ontologyBLASTP
271248127137851305hypothetical proteinBLASTP
271379627149501155hypothetical proteinBLASTP