Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:266543 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2665432676731131oxidoreductaseQuickGO ontologyBLASTP
267670268569900hypothetical proteinBLASTP
26878426885875hypothetical protein
268916269710795hypothetical proteinBLASTP
2697192742634545Rhs-like core proteinQuickGO ontologyBLASTP
274302274724423hypothetical proteinBLASTP
2747272768292103VgrG-like proteinQuickGO ontologyBLASTP
27682627692499hypothetical proteinBLASTP
276946277122177hypothetical proteinBLASTP
277204277692489transcriptional repressorQuickGO ontologyBLASTP
277774277998225hypothetical proteinBLASTP
277977278174198hypothetical protein
278074278265192hypothetical proteinBLASTP
278315278800486hypothetical proteinBLASTP
2788022801721371rhsD proteinQuickGO ontologyBLASTP
2802002830912892Rhs-like proteinQuickGO ontologyBLASTP
283057283515459hypothetical proteinBLASTP
2835212859232403VgrG-like proteinQuickGO ontologyBLASTP