Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2640440 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
264044026430312592outer membrane usher proteinQuickGO ontologyBLASTP
264304726443961350hypothetical proteinBLASTP
26443932645133741pilin chaperoneQuickGO ontologyBLASTP
2645436264550873tRNA-AsnQuickGO ontology
264567326469351263prophage integraseQuickGO ontologyBLASTP
264712926484331305anthranilate synthase component IQuickGO ontologyBLASTP
264846126498641404hypothetical proteinBLASTP
264973426515361803permease and ATP-binding protein of yersiniabactin-iron ABC transporterQuickGO ontologyBLASTP
265152326533251803permease and ATP-binding protein of yersiniabactin-iron ABC transporterQuickGO ontologyBLASTP
26534922654451960AraC-type transcriptional regulator for yersiniabactin uptake and biosynthetic genesQuickGO ontologyBLASTP
265464226607496108HMWP2 nonribosomal peptide synthetaseQuickGO ontologyBLASTP
266083726703289492HMWP1 nonribosomal peptidepolyketide synthaseQuickGO ontologyBLASTP
267026526714251161thiazolinyl-S-HMWP1 reductaseQuickGO ontologyBLASTP
26715692672225657yersiniabactin thioesteraseQuickGO ontologyBLASTP
267222926738061578salicyl-AMP ligaseQuickGO ontologyBLASTP
267393726759582022pesticinyersiniabactin outer membrane receptorQuickGO ontologyBLASTP
26767742677196423hypothetical proteinBLASTP
26772042677758555hypothetical proteinBLASTP
26782722678853582hypothetical proteinBLASTP
26788432679052210hypothetical proteinBLASTP
26792952679408114hypothetical proteinBLASTP
26794522680234783transposaseIS proteinQuickGO ontologyBLASTP
268023126812531023transposaseQuickGO ontologyBLASTP
26819322682156225hypothetical proteinBLASTP
26821662682507342hypothetical proteinBLASTP
26823932683283891ATP-binding component of transport system for maltoseQuickGO ontologyBLASTP