Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2541033 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
254103325421241092hypothetical proteinBLASTP
25423892543081693two-component transcriptional regulatorQuickGO ontologyBLASTP
254308725444781392hisitidine protein kinase sensorQuickGO ontologyBLASTP
25446492544822174hypothetical protein
25448152545177363hypothetical proteinBLASTP
25452322545702471hypothetical proteinBLASTP
254591525469881074hypothetical proteinBLASTP
25477792548684906hypothetical proteinBLASTP
25486902549622933hypothetical proteinBLASTP
25488742548990117hypothetical protein
25496092550559951hypothetical proteinBLASTP
25509002551580681oxidoreductaseQuickGO ontologyBLASTP
25516852552344660hypothetical proteinBLASTP
25524792553117639hypothetical proteinBLASTP
25531732553361189hypothetical protein
255336425554752112hypothetical proteinBLASTP
255605325582152163hypothetical proteinBLASTP
255833525595431209transposaseQuickGO ontologyBLASTP
255966225613201659hypothetical proteinBLASTP
25614902561954465hypothetical proteinBLASTP
256211525633021188hypothetical proteinBLASTP
25632992563883585hypothetical proteinBLASTP