Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2491303 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24905032491306804hypothetical proteinBLASTP
24913032492274972enzymeQuickGO ontologyBLASTP
24924672493279813copper homeostasis proteinQuickGO ontologyBLASTP
24934632494038576hypothetical proteinBLASTP
24940682494226159hypothetical proteinBLASTP
249466524963951731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
249662625013564731hemolysinQuickGO ontologyBLASTP
250138625030201635hemolysin activator proteinQuickGO ontologyBLASTP
250355925050941536virulence factorQuickGO ontologyBLASTP
250536125069711611virulence factorQuickGO ontologyBLASTP
25069792507563585ribosomal-protein-alanine N-acetyltransferaseQuickGO ontologyBLASTP
250785725090621206permeaseQuickGO ontologyBLASTP
25094272510020594hypothetical proteinBLASTP
25104742511034561oxidoreductase componentQuickGO ontologyBLASTP
25110712511919849hypothetical proteinBLASTP
2512097251218387tRNA-SerQuickGO ontologyBLASTP
251244325135971155transcriptional regulatorQuickGO ontologyBLASTP
25135692514399831phosphodiesteraseQuickGO ontologyBLASTP
25163872517253867ABC transporter permeaseQuickGO ontologyBLASTP
25172502518086837ABC transporter permeaseQuickGO ontologyBLASTP