Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2366000 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
236602923675281500carboxypeptidaseQuickGO ontologyBLASTP
23676502368078429transposaseQuickGO ontologyBLASTP
236813123691531023transposaseQuickGO ontologyBLASTP
23691502369932783transposaseIS proteinQuickGO ontologyBLASTP
23703012370891591thymidine kinaseQuickGO ontologyBLASTP
23716412372048408DNA-binding protein HLP-II HU BH2 HD NSQuickGO ontologyBLASTP
237248323738561374UDP-glucose dehydrogenaseQuickGO ontologyBLASTP
237413623751521017Hnr proteinQuickGO ontologyBLASTP
23764862376950465hypothetical proteinBLASTP
23771532377905753formyltetrahydrofolate deformylaseQuickGO ontologyBLASTP
237786823790761209transposaseQuickGO ontologyBLASTP
2379356237943782tRNA-TyrQuickGO ontologyBLASTP
23799482380808861hypothetical proteinBLASTP
23816092382424816exonuclease IIIQuickGO ontologyBLASTP
23825222382908387hypothetical proteinBLASTP
23829212383211291hypothetical proteinBLASTP
238320823851331926DNA topoisomerase IIIQuickGO ontologyBLASTP
238518023862261047selenophosphate synthetaseQuickGO ontologyBLASTP
23862632386412150hypothetical proteinBLASTP
23864512387002552hypothetical proteinBLASTP
238716523890151851protease IV a signal peptide peptidaseQuickGO ontologyBLASTP
238913223901481017cytoplasmic asparaginase IQuickGO ontologyBLASTP
23901632390810648hypothetical proteinBLASTP