Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:2227278 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22264992227281783transposaseIS proteinQuickGO ontologyBLASTP
222727822283001023transposaseQuickGO ontologyBLASTP
222884022315152676CoA-linked acetaldehyde dehydrogenaseQuickGO ontologyBLASTP
22317292231938210hypothetical proteinBLASTP
22323222232966645channel proteinQuickGO ontologyBLASTP
223380422354411638oligopeptide ABC transporter periplasmic binding proteinQuickGO ontologyBLASTP
22355282236448921oligopeptide permease ABC transporter membrane componentQuickGO ontologyBLASTP
22364672237372906oligopeptide ABC transporter permease proteinQuickGO ontologyBLASTP
223738422383851002oligopeptide transporter ATP-binding componentQuickGO ontologyBLASTP
223838222393831002ATP-binding protein of oligopetide ABC transporterQuickGO ontologyBLASTP
22399442240159216hypothetical proteinBLASTP
22404582240832375hypothetical proteinBLASTP
224094622424271482cardiolipin synthetaseQuickGO ontologyBLASTP
22434532243992540outer membrane protein XQuickGO ontologyBLASTP
22439672244095129hypothetical proteinBLASTP
22450602245356297hypothetical proteinBLASTP
22456572246415759energy transducerQuickGO ontologyBLASTP
224645122475751125transposaseQuickGO ontologyBLASTP
22478072248256450hypothetical proteinBLASTP