Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1909880 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
190988019108841005hypothetical proteinBLASTP
19108951911449555hypothetical proteinBLASTP
191152719125461020NADPH-dependent xylose reductaseQuickGO ontologyBLASTP
19125571913060504hypothetical proteinBLASTP
191310719144651359permease major facilitator superfamilyQuickGO ontologyBLASTP
19148591915839981hypothetical proteinBLASTP
19163261917063738transcriptional activator proteinQuickGO ontologyBLASTP
19170561917712657homoserine lactone synthaseQuickGO ontologyBLASTP
19181101918808699hypothetical proteinBLASTP
19188451919006162hypothetical proteinBLASTP
19189771919090114hypothetical protein
19190961919500405hypothetical proteinBLASTP
191980519209261122hypothetical proteinBLASTP
192104819221331086transport proteinQuickGO ontologyBLASTP
19222481922361114hypothetical protein
19227051923346642hypothetical proteinBLASTP
192358619247011116sarcosine oxidase-like proteinQuickGO ontologyBLASTP
192506219262701209transposaseQuickGO ontologyBLASTP
19264931926924432hypothetical proteinBLASTP
19265471926834288hypothetical proteinBLASTP
192706919281151047dihydroorotaseQuickGO ontologyBLASTP
19284281928673246damage-inducible protein IQuickGO ontologyBLASTP
192943819306461209transposaseQuickGO ontologyBLASTP
193074219343923651RNase EQuickGO ontologyBLASTP