Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1851500 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18516721852175504DNA protection during starvation conditionsQuickGO ontologyBLASTP
18524321853208777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
18532311853728498hypothetical proteinBLASTP
18537441854631888transmembrane subunitQuickGO ontologyBLASTP
18546971854801105hypothetical protein
18550301855560531outer membrane protein XQuickGO ontologyBLASTP
18558761856814939hypothetical proteinBLASTP
18570521857594543hypothetical proteinBLASTP
18577361858458723hypothetical proteinBLASTP
185904118602671227hypothetical proteinBLASTP
18604421861359918solute binding protein of ABC transporterQuickGO ontologyBLASTP
186139918628891491ATP-binding component of D-ribose high-affinity transport systemQuickGO ontologyBLASTP
18628861863878993D-ribose high-affinity transport systemQuickGO ontologyBLASTP
186401118650151005transcriptional regulatorQuickGO ontologyBLASTP
18652621866203942transcriptional regulator LYSR-typeQuickGO ontologyBLASTP
186629418673911098tartrate dehydrogenaseQuickGO ontologyBLASTP
186797518696541680quarternary ammonium transport proteinQuickGO ontologyBLASTP
18709211871886966diogenase beta subunitQuickGO ontologyBLASTP
187253918742271689hemolysin activator proteinQuickGO ontologyBLASTP
187423918819787740hemagglutinin-like secreted proteinQuickGO ontologyBLASTP
18819801882489510hypothetical proteinBLASTP
18824621882611150hypothetical proteinBLASTP
18827341882985252hypothetical proteinBLASTP
188363718856822046hemagglutinin-like secreted proteinQuickGO ontologyBLASTP
18856921885889198hypothetical proteinBLASTP
18864011886805405hypothetical proteinBLASTP
18869651887357393hypothetical proteinBLASTP
18876151888160546hypothetical proteinBLASTP
18881091888240132hypothetical protein
18881721888297126hypothetical proteinBLASTP
18882371888368132hypothetical protein
188842518895461122inner membrane ABC transporterQuickGO ontologyBLASTP