Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1801819 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18018191802319501NADH dehydrogenase alpha subunitQuickGO ontologyBLASTP
18024211803098678NADH dehydrogenase beta subunitQuickGO ontologyBLASTP
180323918050351797NADH dehydrogenase I chain C DQuickGO ontologyBLASTP
18050381805601564ATP synthase subunit EQuickGO ontologyBLASTP
180559818069831386NADH dehydrogenase I chain FQuickGO ontologyBLASTP
180707018098142745NADH dehydrogenase gamma subunitQuickGO ontologyBLASTP
18098111810788978NADH dehydrogenase subunit HQuickGO ontologyBLASTP
18108031811345543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
18113581811903546NADH dehydrogenase subunit JQuickGO ontologyBLASTP
18119001812202303NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
181219918140431845NADH dehydrogenase subunit LQuickGO ontologyBLASTP
181408318156151533NADH dehydrogenase subunit MQuickGO ontologyBLASTP
181562218170851464NADH dehydrogenase subunit NQuickGO ontologyBLASTP
181727618185111236hypothetical proteinBLASTP
18188561819083228hypothetical proteinBLASTP
18191411819866726gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
18199151820451537gluconokinase 1QuickGO ontologyBLASTP
18205291820714186hypothetical proteinBLASTP
18206191820855237hypothetical proteinBLASTP
182150918227921284hypothetical proteinBLASTP
18232611824253993LACI-type transcriptional regulatorQuickGO ontologyBLASTP