Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:179775 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
179440179778339hypothetical proteinBLASTP
1797751809081134succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
1811751831301956hypothetical proteinBLASTP
183132184067936hypothetical proteinBLASTP
184075184278204hypothetical proteinBLASTP
184581185492912transcriptional regulator LYSR-typeQuickGO ontologyBLASTP
185744186619876transcriptional regulatorQuickGO ontologyBLASTP
186780186941162hypothetical proteinBLASTP
1870321893562325toxin subunitQuickGO ontologyBLASTP
1893971929903594toxin subunitQuickGO ontologyBLASTP
1929871975374551toxin subunitQuickGO ontologyBLASTP
197671197973303hypothetical proteinBLASTP
197977198387411hypothetical proteinBLASTP
198375198743369hypothetical proteinBLASTP
198730198903174hypothetical proteinBLASTP
1989442017752832toxin subunitQuickGO ontologyBLASTP