Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1622941 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
162294116244731533sialic acid transporterQuickGO ontologyBLASTP
162478816258251038thiosulfate binding periplasmic protein of sulfatethiosulfate ABC transporterQuickGO ontologyBLASTP
16258251626658834inner membrane permease T of sulfatethiosulfate ABC transporterQuickGO ontologyBLASTP
16266581627533876sulfatethiosulfate permeaseQuickGO ontologyBLASTP
162749616286141119ATP-binding component of sulfate permease A proteinQuickGO ontologyBLASTP
16287851629663879cysteine synthase B O-acetylserine sulfhydrolase BQuickGO ontologyBLASTP
162990816311401233hypothetical proteinBLASTP
16315211632228708response regulatorQuickGO ontologyBLASTP
163222516337691545sensor kinaseQuickGO ontologyBLASTP
163400216355311530hypothetical proteinBLASTP
163608316373091227aminotransferaseQuickGO ontologyBLASTP
16373281637534207hypothetical proteinBLASTP
16375911638562972hypothetical proteinBLASTP
163889916403591461permeaseQuickGO ontologyBLASTP
164041916420651647NADH oxidaseQuickGO ontologyBLASTP
164232016443562037ATP-binding component of a transport systemQuickGO ontologyBLASTP
164436016455651206membrane protein possible efflux componentQuickGO ontologyBLASTP