Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1510467 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15104671511423957hypothetical proteinBLASTP
15114721511696225hypothetical proteinBLASTP
15116301511821192hypothetical proteinBLASTP
151179715131761380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
151326215148091548inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
151498915165661578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP
15168901517399510transposaseQuickGO ontologyBLASTP
15175591518038480hypothetical proteinBLASTP
15180621518460399hypothetical proteinBLASTP
15185241518943420hypothetical proteinBLASTP
15189811519376396hypothetical proteinBLASTP
15194401519835396hypothetical proteinBLASTP
15198321520554723hypothetical proteinBLASTP
152055815217661209transposaseQuickGO ontologyBLASTP
15221151522594480hypothetical proteinBLASTP
15231041523904801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
15239661524712747hypothetical proteinBLASTP
15246841524854171hypothetical proteinBLASTP
15250851525594510hypothetical proteinBLASTP
15256201525859240hypothetical protein
15258811526771891hypothetical proteinBLASTP
152740715288011395hypothetical proteinBLASTP
15290761529459384hypothetical proteinBLASTP
15295511530270720transcriptional response regulatory protein sensor BaeSQuickGO ontologyBLASTP
153169515330921398permease major facilitator superfamilyQuickGO ontologyBLASTP