Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1387276 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
138727613889281653urease urea amidohydrolase alpha subunitQuickGO ontologyBLASTP
13892151389919705urease accessory proteinQuickGO ontologyBLASTP
13899411390627687urease accessory proteinQuickGO ontologyBLASTP
13907541391416663urease accessory proteinQuickGO ontologyBLASTP
13925711393563993hypothetical proteinBLASTP
139368813947701083nickel transport proteinQuickGO ontologyBLASTP
13949391395268330hypothetical proteinBLASTP
139588613970611176potassium channelQuickGO ontologyBLASTP
13971591397569411camphor resistance protein CrcBQuickGO ontologyBLASTP
13975791397959381camphor resistance protein CrcBQuickGO ontologyBLASTP
13980481398227180hypothetical proteinBLASTP
13989701399317348PEP-dependent phosphotransferase enzyme IV for cellobiose arbutin and salicinQuickGO ontologyBLASTP
139932814006891362PEP-dependent phosphotransferase enzyme II for cellobiose arbutin and salicinQuickGO ontologyBLASTP
14008561401203348PEP-dependent phosphotransferase IIA component for cellobiose arbutin and salicinQuickGO ontologyBLASTP
14012401402082843negative transcriptional regulator of cel operonQuickGO ontologyBLASTP
14021341402895762hypothetical proteinBLASTP
14031901403558369hypothetical proteinBLASTP
14040381404580543negative modulator of initiation of replicationQuickGO ontologyBLASTP
140461114062961686phosphoglucomutaseQuickGO ontologyBLASTP