Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1265730 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
126573012681112382beta-glucosidaseQuickGO ontologyBLASTP
12682701268800531hypothetical proteinBLASTP
126879312710002208hypothetical proteinBLASTP
1271012127111099hypothetical protein
127145212726601209transposaseQuickGO ontologyBLASTP
12727391273047309hypothetical proteinBLASTP
127417812760941917autotransporterQuickGO ontologyBLASTP
12771811277432252hypothetical proteinBLASTP
12774561278028573hypothetical proteinBLASTP
12780401278441402hypothetical proteinBLASTP
12786741279114441hypothetical proteinBLASTP
12793431279924582hypothetical proteinBLASTP
12805401280842303regulatorQuickGO ontologyBLASTP
128105512835922538penicillin-binding proteinQuickGO ontologyBLASTP
12835621284071510transposaseQuickGO ontologyBLASTP
128418612902006015hypothetical proteinBLASTP