Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1196875 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11968751197207333hypothetical proteinBLASTP
11972071197812606recombination protein RecRQuickGO ontologyBLASTP
11978271197985159hypothetical proteinBLASTP
119800411998781875heat shock protein 90QuickGO ontologyBLASTP
12001051200749645adenylate kinaseQuickGO ontologyBLASTP
12008391201801963ferrochelataseQuickGO ontologyBLASTP
12023991203388990CDP-6-deoxy-delta-34-glucoseen reductaseQuickGO ontologyBLASTP
12034141204199786glucose-1-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
12043401205278939CDP-D-glucose-46-dehydrataseQuickGO ontologyBLASTP
120529612066091314CDP-4-keto-6-deoxy-d-glucose-3-dehydraseQuickGO ontologyBLASTP
12066461207503858CDP-paratose synthetaseQuickGO ontologyBLASTP
120750412087871284O-antigen synthesis protein WbyHQuickGO ontologyBLASTP
120884912102041356O-unit flippase-like proteinQuickGO ontologyBLASTP
1209970121006596hypothetical protein
12102151210928714glycosyltransferaseQuickGO ontologyBLASTP
121130812124501143mannosyltransferase proteinQuickGO ontologyBLASTP
121388112149301050mannosyltransferase-like proteinQuickGO ontologyBLASTP
12160741217039966nucleotide di-P-sugar epimerase or dehydrataseQuickGO ontologyBLASTP
121722012186321413mannose-1-phosphate guanyltransferaseQuickGO ontologyBLASTP
12186351219378744glycosyltransferaseQuickGO ontologyBLASTP
121938312207561374phosphomannomutaseQuickGO ontologyBLASTP
122080412219551152O-antigen chain length determinantQuickGO ontologyBLASTP
122215912234631305inosine-guanosine kinaseQuickGO ontologyBLASTP
122356012252511692potassium efflux proteinQuickGO ontologyBLASTP
122548612267001215drug efflux proteinQuickGO ontologyBLASTP
12287411229025285hypothetical proteinBLASTP
12293171229805489hypothetical proteinBLASTP
12300601230869810ligaseQuickGO ontologyBLASTP
123139012342752886cation-translocating ATPaseQuickGO ontologyBLASTP
12336501233832183hypothetical protein