Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:1075454 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10746041075461858Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
10754541076083630NADH-ubiquinone oxidoreductaseQuickGO ontologyBLASTP
10760841076686603Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
107670210779251224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
107790610789881083hypothetical proteinBLASTP
10794721080419948hypothetical proteinBLASTP
108076310818331071DNA polymerase IVQuickGO ontologyBLASTP
108194710834071461aminoacyl-histidine dipeptidase peptidase DQuickGO ontologyBLASTP
10852821086193912LysR-type transcriptional regulatory proteinQuickGO ontologyBLASTP
108665310882571605hypothetical proteinBLASTP
10891861089644459xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
108975310910181266hypothetical proteinBLASTP
10910781091479402transcriptional regulator of cryptic csgA gene for curli surface fibersQuickGO ontologyBLASTP
109165610927591104gamma-glutamyl kinaseQuickGO ontologyBLASTP
109276910940281260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
10943561095114759hypothetical proteinBLASTP
10952971095566270hypothetical proteinBLASTP
10958121096333522biotin synthesis proteinQuickGO ontologyBLASTP
10970331097620588hypothetical proteinBLASTP
10978671098391525shikimate kinase IIQuickGO ontologyBLASTP
10988811099168288hypothetical proteinBLASTP