Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:674265 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
674265675170906oligopeptide ABC transporter permease proteinQuickGO ontologyBLASTP
675189676157969oligopeptide ABC transporter permease proteinQuickGO ontologyBLASTP
676172677098927oligopeptide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
6783886797371350glycerol-3-phosphate transporterQuickGO ontologyBLASTP
680010680468459transcriptional regulator MarR familyQuickGO ontologyBLASTP
682226683197972ribose operon repressorQuickGO ontologyBLASTP
683211684107897ribokinaseQuickGO ontologyBLASTP
684104684499396ribose ABC transporter proteinQuickGO ontologyBLASTP
6846176860021386ribose ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
686005686940936ribose ABC transporter permease proteinQuickGO ontologyBLASTP
686955687881927ribose ABC transporter ribose-binding proteinQuickGO ontologyBLASTP
687916688563648transaldolaseQuickGO ontologyBLASTP
6888806912792400immune inhibitor A metalloproteaseQuickGO ontologyBLASTP
691598691939342hypothetical proteinBLASTP
6919776931491173multidrug resistance protein putativeQuickGO ontologyBLASTP