Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:5200805 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
52008055201599795metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
52015835202425843yycI proteinQuickGO ontologyBLASTP
520240652037221317YycH proteinQuickGO ontologyBLASTP
520371952055601842sensory box histidine kinase YycGQuickGO ontologyBLASTP
52055645206271708DNA-binding response regulator YycFQuickGO ontologyBLASTP
5206675520674773tRNA-PheQuickGO ontology
5206885520695672tRNA-GluQuickGO ontologyBLASTP
5206970520704576tRNA-LysQuickGO ontologyBLASTP
520718552084741290adenylosuccinate synthetaseQuickGO ontologyBLASTP
520869052100511362replicative DNA helicaseQuickGO ontologyBLASTP
5210079521052544750S ribosomal protein L9QuickGO ontologyBLASTP
521052252124951974DHH subfamily 1 proteinQuickGO ontologyBLASTP
52125745213512939hypothetical proteinBLASTP
5213590521382323430S ribosomal protein S18QuickGO ontologyBLASTP
52138695214387519single-strand DNA-binding proteinQuickGO ontologyBLASTP
5214417521470729130S ribosomal protein S6QuickGO ontologyBLASTP
521489952159991101GTP-binding protein YchFQuickGO ontologyBLASTP
52161155216312198hypothetical proteinBLASTP
52163335217214882mechanosensitive ion channel family proteinQuickGO ontologyBLASTP
52174745218070597hypothetical proteinBLASTP
52180915218861771stage 0 sporulation protein JQuickGO ontologyBLASTP
52189355219696762sporulation initiation inhibitor protein SojQuickGO ontologyBLASTP
52198875220759873stage 0 sporulation protein J putativeQuickGO ontologyBLASTP
52208645221583720glucose-inhibited division protein BQuickGO ontologyBLASTP
522160552234941890glucose-inhibited division protein AQuickGO ontologyBLASTP