Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:5032969 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
503296950356982730sensory boxGGDEF family proteinQuickGO ontologyBLASTP
50357705036423654hypothetical proteinBLASTP
50364715037262792hypothetical proteinBLASTP
50373845037785402ATP synthase subunit epsilonQuickGO ontologyBLASTP
503780650392151410ATP synthase subunit BQuickGO ontologyBLASTP
50393355040195861ATP synthase subunit CQuickGO ontologyBLASTP
504053150420391509ATP synthase subunit AQuickGO ontologyBLASTP
50420515042593543ATP synthase subunit DQuickGO ontologyBLASTP
50425905043096507ATP synthase subunit BQuickGO ontologyBLASTP
50432245043442219ATP synthase subunit CQuickGO ontologyBLASTP
50434995044218720ATP synthase subunit AQuickGO ontologyBLASTP
50442265044618393ATP synthase protein IQuickGO ontologyBLASTP
50446185044872255hypothetical proteinBLASTP
50448695044982114hypothetical proteinBLASTP
50453545045983630uracil phosphoribosyltransferaseQuickGO ontologyBLASTP
504625550474961242serine hydroxymethyltransferaseQuickGO ontologyBLASTP
50477135048285573conserved hypothetical protein TIGR01440QuickGO ontologyBLASTP
50483525048795444ribose-5-phosphate isomerase BQuickGO ontologyBLASTP
50488925049332441low molecular weight phosphotyrosine protein phosphatase family proteinQuickGO ontologyBLASTP
50495805050077498PTS system glucose-specific IIA component putativeQuickGO ontologyBLASTP
50504645050850387hypothetical proteinBLASTP
50510105051621612hypothetical proteinBLASTP
50518145052158345hypothetical proteinBLASTP
50523235052871549hypothetical proteinBLASTP
505294950539891041sua5yciOyrdCywlC family proteinQuickGO ontologyBLASTP
50540985054556459hypothetical proteinBLASTP
50546065055472867stage II sporulation protein R putativeQuickGO ontologyBLASTP
50555855056436852modification methylase HemK familyQuickGO ontologyBLASTP
505643650575031068peptide chain release factor 1QuickGO ontologyBLASTP
50577745058358585thymidine kinaseQuickGO ontologyBLASTP
5058467505871224650S ribosomal protein L31QuickGO ontologyBLASTP
505911650603871272transcription termination factor RhoQuickGO ontologyBLASTP
50607305061695966fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
50617115061812102hypothetical proteinBLASTP
506181350631021290UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50634345064291858fructose-bisphosphate aldolaseQuickGO ontologyBLASTP
50645025064870369stage 0 sporulation protein FQuickGO ontologyBLASTP
50650725065596525hypothetical proteinBLASTP
506562850672351608CTP synthetaseQuickGO ontologyBLASTP
50674935068020528DNA-directed RNA polymerase delta subunitQuickGO ontologyBLASTP
50681755068777603transcriptional regulator TetR familyQuickGO ontologyBLASTP
506886950700081140acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507003050711601131acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507123450720858523-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP