Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:5006193 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
500619350087572565hypothetical proteinBLASTP
50087575009020264hypothetical proteinBLASTP
500927350105711299glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501052250117631242glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501205750130581002mbl proteinQuickGO ontologyBLASTP
50132205013618399stage III sporulation protein DQuickGO ontologyBLASTP
50138975014277381lipoprotein putativeQuickGO ontologyBLASTP
50144335014567135hypothetical proteinBLASTP
50147095015614906stage II sporulation proteinQuickGO ontologyBLASTP
50157765016480705ABC transporter permease protein putativeQuickGO ontologyBLASTP
50164805017322843ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
501863950196581020stage II sporulation protein DQuickGO ontologyBLASTP
501986650211701305UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50212105021920711hypothetical proteinBLASTP
50219665022202237hypothetical proteinBLASTP
502256850240881521NADH dehydrogenase subunit NQuickGO ontologyBLASTP
502409050255831494NADH dehydrogenase subunit MQuickGO ontologyBLASTP
502558050273941815NADH dehydrogenase subunit LQuickGO ontologyBLASTP
50274725027786315NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
50277795028303525NADH dehydrogenase subunit JQuickGO ontologyBLASTP
50283005028719420NADH dehydrogenase subunit IQuickGO ontologyBLASTP
502874550297461002NADH dehydrogenase subunit HQuickGO ontologyBLASTP
502974650308461101NADH dehydrogenase delta subunitQuickGO ontologyBLASTP