Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4876415 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48764154877221807hypothetical proteinBLASTP
48773844878340957thioredoxin reductaseQuickGO ontologyBLASTP
487842548799361512TPR domain proteinQuickGO ontologyBLASTP
48800764880588513bacterial transferase hexapeptide domain proteinQuickGO ontologyBLASTP
48806124881262651hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
48813304882142813prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
48821674883096930HPr kinasephosphorylaseQuickGO ontologyBLASTP
48832534883633381hypothetical proteinBLASTP
48837484884197450hypothetical proteinBLASTP
488425748871332877excinuclease ABC subunit AQuickGO ontologyBLASTP
488713948891151977excinuclease ABC subunit BQuickGO ontologyBLASTP
488927648904331158transposase IS605 familyQuickGO ontologyBLASTP
48908514891282432lipoprotein putativeQuickGO ontologyBLASTP
48913284891948621hypothetical proteinBLASTP
48919454892706762transcriptional regulator MerR familyQuickGO ontologyBLASTP
48928064892955150hypothetical proteinBLASTP
48930504893442393hypothetical proteinBLASTP
48934394893660222hypothetical proteinBLASTP
48936734893885213DNA-binding proteinQuickGO ontologyBLASTP
489420548952271023hypothetical proteinBLASTP
48953784896271894transcriptional regulator LysR familyQuickGO ontologyBLASTP
48963234896688366transcriptional regulator MerR familyQuickGO ontologyBLASTP
48966934897238546FMN reductase NADPH-dependentQuickGO ontologyBLASTP
489750448991381635macrolide efflux pump putativeQuickGO ontologyBLASTP
489961949013341716ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
490164649028301185hypothetical proteinBLASTP
490294049043491410carboxyl-terminal proteaseQuickGO ontologyBLASTP
49044954905388894cell division ABC transporter permease protein FtsXQuickGO ontologyBLASTP
49053784906022645cell division ABC transporter ATP-binding protein FtsEQuickGO ontologyBLASTP
49063514906674324cytochrome c-551QuickGO ontologyBLASTP
49069294907111183hypothetical proteinBLASTP
490835449108612508translocaseQuickGO ontologyBLASTP
49111384911680543ribosomal subunit interface proteinQuickGO ontologyBLASTP
49120044912201198cold shock protein CspCQuickGO ontologyBLASTP
49123284912900573comF operon protein 3QuickGO ontologyBLASTP
491303249143811350comF operon protein 1QuickGO ontologyBLASTP
491450949158191311endopeptidase lytE putativeQuickGO ontologyBLASTP
49160714916385315hypothetical proteinBLASTP
49164564916578123hypothetical proteinBLASTP
49165594917401843degV family proteinQuickGO ontologyBLASTP
49176414918276636conserved hypothetical protein TIGR00257QuickGO ontologyBLASTP
491835149194781128transcription antiterminator LytR familyQuickGO ontologyBLASTP
491951249206271116UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP