Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4852332 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485233248536421311hypothetical proteinBLASTP
48536144854111498prophage LambdaBa03 prohead protease putativeQuickGO ontologyBLASTP
485417148552111041phage major capsid protein HK97 familyQuickGO ontologyBLASTP
48552984856278981hypothetical proteinBLASTP
48563464857212867hypothetical proteinBLASTP
48573354858240906prophage LambdaBa03 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
485838448596791296enolaseQuickGO ontologyBLASTP
485971048612391530phosphoglyceromutaseQuickGO ontologyBLASTP
48612364861991756triosephosphate isomeraseQuickGO ontologyBLASTP
486202448632081185phosphoglycerate kinaseQuickGO ontologyBLASTP
486334848643521005glyceraldehyde-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
486437948654071029gapA transcriptional regulator CggRQuickGO ontologyBLASTP
48655444865789246glutaredoxin family proteinQuickGO ontologyBLASTP
486579948671061308DNA-directed RNA polymerase subunit NQuickGO ontologyBLASTP
4867362486744079tRNA-ArgQuickGO ontologyBLASTP
48676464867852207hypothetical proteinBLASTP
48679464868431486lipoprotein putativeQuickGO ontologyBLASTP
48684624868938477stage V sporulation protein ACQuickGO ontologyBLASTP
486893948699551017stage V sporulation protein SpoVADQuickGO ontologyBLASTP
48699524870302351stage V sporulation protein AEQuickGO ontologyBLASTP
48703144870520207hypothetical proteinBLASTP
48705414871410870hypothetical proteinBLASTP
48716524872233582ATP-dependent Clp protease proteolytic subunitQuickGO ontologyBLASTP
48725574872805249phosphocarrier protein HPrQuickGO ontologyBLASTP
48728294873779951hypothetical proteinBLASTP
48738694874822954hypothetical proteinBLASTP