Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4745027 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
47450274745557531lipoprotein putativeQuickGO ontologyBLASTP
47457014746348648PAP2 family proteinQuickGO ontologyBLASTP
474640547474181014hypothetical proteinBLASTP
47474414748391951L-lactate dehydrogenaseQuickGO ontologyBLASTP
47486374748885249spore coat protein F-related proteinQuickGO ontologyBLASTP
47488994749084186hypothetical proteinBLASTP
47492314749914684CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
47505324751080549transcriptional regulator putativeQuickGO ontologyBLASTP
47510844751806723metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
475194547537291785acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
47538824753998117hypothetical proteinBLASTP
475400447551761173acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
4755198475757923823-hydroxyacyl-CoA dehydrogenaseenoyl-CoA hydrataseisomerase family proteinQuickGO ontologyBLASTP
4757677475777599hypothetical proteinBLASTP
47578154757961147hypothetical proteinBLASTP
47580494758888840D-alanyl-D-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
47589114759828918proline dehydrogenase family proteinQuickGO ontologyBLASTP
47601384760383246hypothetical proteinBLASTP
47604324760734303conserved hypothetical protein TIGR00106QuickGO ontologyBLASTP
476081247628122001methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
47630014763759759hypothetical proteinBLASTP
476379047656731884cell wall surface anchor family proteinQuickGO ontologyBLASTP