Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:467993 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4679934691831191prophage LambdaBa04 major capsid protein putativeQuickGO ontologyBLASTP
469199469456258hypothetical proteinBLASTP
469453469725273prophage LambdaBa04 DNA packaging protein putativeQuickGO ontologyBLASTP
469722470021300hypothetical proteinBLASTP
470014470370357hypothetical proteinBLASTP
470367470696330hypothetical proteinBLASTP
470697471266570prophage LambdaBa04 major tail protein putativeQuickGO ontologyBLASTP
471271471633363hypothetical proteinBLASTP
471744471857114hypothetical proteinBLASTP
4718754758103936prophage LambdaBa04 tape measure protein putativeQuickGO ontologyBLASTP
475807476616810hypothetical proteinBLASTP
4766314802093579hypothetical proteinBLASTP
480275480436162hypothetical proteinBLASTP
4805054821391635phage minor structural proteinQuickGO ontologyBLASTP
482157482636480hypothetical proteinBLASTP
482731482970240hypothetical proteinBLASTP
483043483186144hypothetical proteinBLASTP
483186483983798prophage LambdaBa04 glycosyl hydrolase family 25 putativeQuickGO ontologyBLASTP
484037484339303hypothetical proteinBLASTP
485540485743204hypothetical proteinBLASTP
4858274872301404arginine utilization regulatory protein RocRQuickGO ontologyBLASTP
487504487758255acetyl-CoA carboxylaseQuickGO ontologyBLASTP
4878634892841422amino acid permease family proteinQuickGO ontologyBLASTP
4893804906601281acetylornithine deacetylaseQuickGO ontologyBLASTP