Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4507939 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45079394508370432hypothetical proteinBLASTP
45087434509021279hypothetical proteinBLASTP
45090564509238183hypothetical proteinBLASTP
45092404509476237hypothetical proteinBLASTP
45097474510193447transcriptional regulator CarD familyQuickGO ontologyBLASTP
45102534511038786glucose-1-dehydrogenaseQuickGO ontologyBLASTP
45110524511909858glucose uptake proteinQuickGO ontologyBLASTP
45119464512365420hypothetical proteinBLASTP
45124594512692234molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
45126954513159465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
45131564513671516molybdopterin-guanine dinucleotide biosynthesis protein MobBQuickGO ontologyBLASTP
451364145149301290molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
45150144515499486molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
451553845165511014molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
451775745191661410collagen triple helix repeat domain proteinQuickGO ontologyBLASTP
45193404519663324hypothetical proteinBLASTP
45196844519908225hypothetical proteinBLASTP
45199864520291306rhodanese-like domain proteinQuickGO ontologyBLASTP
45204924520674183hypothetical proteinBLASTP
452072445218481125homoserine O-acetyltransferaseQuickGO ontologyBLASTP
452200145242442244spore germination protein GerHAQuickGO ontologyBLASTP
452426245253561095spore germination protein GerHBQuickGO ontologyBLASTP
452533245264111080spore germination protein GerHCQuickGO ontologyBLASTP
45264904526687198hypothetical proteinBLASTP