Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4473973 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44739734474269297minD family ATPase domain proteinQuickGO ontologyBLASTP
44743514474587237hypothetical proteinBLASTP
44745774474951375hypothetical proteinBLASTP
44749864475984999catabolite control protein AQuickGO ontologyBLASTP
447651344775291017lipoprotein putativeQuickGO ontologyBLASTP
44776474477973327hypothetical proteinBLASTP
44779734478485513hypothetical proteinBLASTP
447867344797881116aminopeptidase putativeQuickGO ontologyBLASTP
44798254480259435lipoprotein putativeQuickGO ontologyBLASTP
44802754480457183hypothetical proteinBLASTP
44804544480858405hypothetical proteinBLASTP
44809504481504555ribosomal-protein-serine acetyltransferase putativeQuickGO ontologyBLASTP
448170144830111311UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
448326444843821119nicotinate phosphoribosyltransferaseQuickGO ontologyBLASTP
448444444883793936FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
44886014488945345hypothetical proteinBLASTP
44893804489994615tRNA binding domain protein putativeQuickGO ontologyBLASTP
44899914490803813hypothetical proteinBLASTP
44908834491197315thioredoxin family proteinQuickGO ontologyBLASTP
44912814491790510hypothetical proteinBLASTP
449203244931051074peptidase M42 familyQuickGO ontologyBLASTP
44932544493565312hypothetical proteinBLASTP
44938014494655855metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
44947254495378654tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
44956114495889279hypothetical proteinBLASTP
44958934496684792aminoglycoside phosphotransferase family proteinQuickGO ontologyBLASTP