Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4399067 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43990674400005939malate dehydrogenaseQuickGO ontologyBLASTP
440002544013171293isocitrate dehydrogenaseQuickGO ontologyBLASTP
440147844025931116citrate synthaseQuickGO ontologyBLASTP
44030144403475462hypothetical proteinBLASTP
440391744050141098hypothetical proteinBLASTP
44056004405989390fxsA cytoplasmic membrane protein putativeQuickGO ontologyBLASTP
440618944079461758pyruvate kinaseQuickGO ontologyBLASTP
440800044089599606-phosphofructokinaseQuickGO ontologyBLASTP
44090884410062975acetyl-CoA carboxylase alpha subunitQuickGO ontologyBLASTP
44100504410919870acetyl-CoA carboxylase beta subunitQuickGO ontologyBLASTP
44111054411749645transcriptional regulator GntR familyQuickGO ontologyBLASTP
441176444129721209malate dehydrogenase putativeQuickGO ontologyBLASTP
441310644164323327DNA polymerase III subunit alphaQuickGO ontologyBLASTP
44165504416888339hypothetical proteinBLASTP
44168854417388504hypothetical proteinBLASTP
44174404418372933DHH subfamily 1 proteinQuickGO ontologyBLASTP