Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4273579 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
427357942749131335glutamyl-tRNA reductaseQuickGO ontologyBLASTP
42753294275781453transcriptional regulator MarR familyQuickGO ontologyBLASTP
42757844276200417organic hydroperoxide resistance proteinQuickGO ontologyBLASTP
42762334276829597GTP-binding proteinQuickGO ontologyBLASTP
427682642791472322ATP-dependent protease La 1QuickGO ontologyBLASTP
427934042810131674ATP-dependent protease LAQuickGO ontologyBLASTP
428111742823761260ATP-dependent protease ATP-binding subunitQuickGO ontologyBLASTP
428264142839181278trigger factorQuickGO ontologyBLASTP
42842294285227999hypothetical proteinBLASTP
42854254285673249hypothetical proteinBLASTP
42859614286113153hypothetical proteinBLASTP
42861934286807615hypothetical proteinBLASTP
42868934287093201hypothetical proteinBLASTP
42876384287790153hypothetical proteinBLASTP
42877624288265504phosphoesterase putativeQuickGO ontologyBLASTP
42882794288887609HAM1 proteinQuickGO ontologyBLASTP
42888994289636738ribonuclease PHQuickGO ontologyBLASTP
428976542908141050germination protein gerMQuickGO ontologyBLASTP
42909454291754810glutamate racemaseQuickGO ontologyBLASTP