Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:4116944 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41164774116947471hypothetical proteinBLASTP
411694441190882145HDIG domain proteinQuickGO ontologyBLASTP
41192824120241960PhoH family proteinQuickGO ontologyBLASTP
412024541214441200sporulation proteinQuickGO ontologyBLASTP
41214344121544111hypothetical proteinBLASTP
41216214121914294hypothetical proteinBLASTP
41220234122466444gatBYqey domain proteinQuickGO ontologyBLASTP
4122482412265517430S ribosomal protein S21QuickGO ontologyBLASTP
412298641243381353hypothetical proteinBLASTP
41243454125001657conserved hypothetical protein TIGR00046QuickGO ontologyBLASTP
41252404126178939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
412620741273221116chaperone protein dnaJQuickGO ontologyBLASTP
412752741293621836molecular chaperone DnaKQuickGO ontologyBLASTP
41293894129955567GrpE proteinQuickGO ontologyBLASTP
413007041310861017heat-inducible transcription repressorQuickGO ontologyBLASTP
413122041323561137coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
41324124132786375hypothetical proteinBLASTP
413291841347411824GTP-binding protein LepAQuickGO ontologyBLASTP
41349524135314363hypothetical proteinBLASTP
413531441364201107germination protease precursorQuickGO ontologyBLASTP
4136593413685926730S ribosomal protein S20QuickGO ontologyBLASTP
413694241379521011hypothetical proteinBLASTP