Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3993223 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39932233993648426mutTnudix family proteinQuickGO ontologyBLASTP
399381539949931179cell division protein FtsWRodASpoVE familyQuickGO ontologyBLASTP
399533539966541320dihydrolipoamide acetyltransferaseQuickGO ontologyBLASTP
399667039976539843-methyl-2-oxobutanoate dehydrogenase beta subunitQuickGO ontologyBLASTP
3997667399866810023-methyl-2-oxobutanoate dehydrogenase alpha subunitQuickGO ontologyBLASTP
399869640001171422dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
400012240012251104butyrate kinaseQuickGO ontologyBLASTP
400131340024131101leucine dehydrogenaseQuickGO ontologyBLASTP
40024484003347900phosphate acetyltransferaseQuickGO ontologyBLASTP
400354340056152073sensory box sigma-54 dependent DNA-binding response regulatorQuickGO ontologyBLASTP
40057524005985234hypothetical proteinBLASTP
40060344006762729glycerophosphoryl diester phosphodiesterase family proteinQuickGO ontologyBLASTP
40068134006959147hypothetical proteinBLASTP
400712740086531527hypothetical proteinBLASTP
40089514009745795stage 0 sporulation protein AQuickGO ontologyBLASTP
401003340113311299stage IV sporulation protein BQuickGO ontologyBLASTP