Pre_GI Gene

Some Help

Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3692776 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
369277636944851710fibronectinfibrinogen-binding protein putativeQuickGO ontologyBLASTP
369481336958831071proline dipeptidase putativeQuickGO ontologyBLASTP
36958633696006144hypothetical proteinBLASTP
36960033696371369hypothetical proteinBLASTP
36963873696752366hypothetical proteinBLASTP
369691936983041386hypothetical proteinBLASTP
36984713698725255hypothetical proteinBLASTP
36994673700099633orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37000963700812717orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
37007973701726930dihydroorotate dehydrogenaseQuickGO ontologyBLASTP
37017233702502780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
370249937057173219carbamoyl-phosphate synthase large subunitQuickGO ontologyBLASTP
370570237067991098carbamoyl-phosphate synthase small subunitQuickGO ontologyBLASTP
370679637080821287dihydroorotaseQuickGO ontologyBLASTP
37080663708980915aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
370912937104121284uracil permeaseQuickGO ontologyBLASTP
37105593711101543pyrimidine regulatory protein PyrRQuickGO ontologyBLASTP