Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3579972 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35799723580514543spore coat protein EQuickGO ontologyBLASTP
35806403581071432hypothetical proteinBLASTP
358107535826041530hypothetical proteinBLASTP
35830323583898867ferrodoxin oxidoreductase beta subunitQuickGO ontologyBLASTP
358388535856421758pyruvate ferredoxin oxidoreductase alpha subunit putativeQuickGO ontologyBLASTP
35858703586793924renal dipeptidase family proteinQuickGO ontologyBLASTP
35868533587113261stage V sporulation protein SQuickGO ontologyBLASTP
35872633588057795phosphoesterase family proteinQuickGO ontologyBLASTP
358822335897851563hypothetical proteinBLASTP
359177135930091239competence damage-inducible protein AQuickGO ontologyBLASTP
35930303593608579CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
35936723594583912hypothetical proteinBLASTP
35946053595390786ACT domain proteinQuickGO ontologyBLASTP
35955303595778249hypothetical proteinBLASTP
359585435965677143-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
359667135979571287zinc protease insulinase familyQuickGO ontologyBLASTP
359795835992321275hypothetical proteinBLASTP