Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3462497 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346249734645032007hypothetical proteinBLASTP
346457934672302652prophage LambdaBa01 minor structural proteinQuickGO ontologyBLASTP
346874934711842436prophage LambdaBa01 membrane protein putativeQuickGO ontologyBLASTP
347139934726461248hypothetical proteinBLASTP
34726623472823162hypothetical proteinBLASTP
34728673473238372hypothetical proteinBLASTP
34732433473836594prophage LambdaBa01 major tail protein putativeQuickGO ontologyBLASTP
34738373474166330hypothetical proteinBLASTP
34741633474519357hypothetical proteinBLASTP
34745123474811300hypothetical proteinBLASTP
34748083475086279hypothetical proteinBLASTP
34750833475373291hypothetical proteinBLASTP
347541034765731164phage major capsid protein putativeQuickGO ontologyBLASTP
34765873477171585prophage LambdaBa01 prohead protease putativeQuickGO ontologyBLASTP
347713734783481212hypothetical proteinBLASTP
347836434800521689prophage LambdaBa01 terminase large subunit putativeQuickGO ontologyBLASTP
34800493480420372hypothetical proteinBLASTP
34805863480711126hypothetical proteinBLASTP
34812133481374162hypothetical proteinBLASTP
34816463482068423hypothetical proteinBLASTP