Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3414441 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
341444134159581518histidine ammonia-lyaseQuickGO ontologyBLASTP
34160633416503441anti-terminator HutPQuickGO ontologyBLASTP
34166973417644948hypothetical proteinBLASTP
34176583418230573thiJpfpI family proteinQuickGO ontologyBLASTP
34182273418727501hypothetical proteinBLASTP
34186993418914216hypothetical proteinBLASTP
34190123419308297hypothetical proteinBLASTP
34194123419852441hypothetical proteinBLASTP
341988234209611080hypothetical proteinBLASTP
34212293421456228conserved repeat domain proteinQuickGO ontologyBLASTP
34215183421835318hypothetical proteinBLASTP
34220433422171129hypothetical proteinBLASTP
34222923422522231hypothetical proteinBLASTP
342248834287906303conserved repeat domain proteinQuickGO ontologyBLASTP
34288533429359507ccdC proteinQuickGO ontologyBLASTP
34294503430157708cytochrome c-type biogenesis protein CcdAQuickGO ontologyBLASTP
34303623430937576hypothetical proteinBLASTP
34311683432073906als operon regulatory protein AlsR putativeQuickGO ontologyBLASTP
34322263432591366holin-like proteinQuickGO ontologyBLASTP
34325883433265678hypothetical proteinBLASTP
34332783433691414mutTnudix family proteinQuickGO ontologyBLASTP
34338333434033201hypothetical proteinBLASTP
34352153435361147hypothetical proteinBLASTP
343552634372531728N-acetylmuramoyl-L-alanine amidase family 2QuickGO ontologyBLASTP
34374693438035567hypothetical proteinBLASTP
34380423438878837hypothetical proteinBLASTP
343918034409431764ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
344094334426941752ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP