Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:3320906 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
332090633227591854squalene-hopene cyclaseQuickGO ontologyBLASTP
33228593323284426hypothetical proteinBLASTP
33233643324305942rarD proteinQuickGO ontologyBLASTP
33243963324596201hypothetical proteinBLASTP
33248133325211399hypothetical proteinBLASTP
33252543325478225hypothetical proteinBLASTP
332549433265431050mrp proteinQuickGO ontologyBLASTP
33266103326846237molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
33268513327315465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
332729633286031308molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
332862233296381017molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
33296633330442780formate transporter putativeQuickGO ontologyBLASTP
33304293330536108hypothetical proteinBLASTP
333063233316481017molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
33316693332466798formate dehydrogenase accessory proteinQuickGO ontologyBLASTP
33324833332827345hypothetical proteinBLASTP
33329433333425483hypothetical proteinBLASTP
333343733363762940molybdopterin oxidoreductase family proteinQuickGO ontologyBLASTP
33363453336536192hypothetical proteinBLASTP
333667433382121539spore germination proteinQuickGO ontologyBLASTP
333820933393061098spore germination proteinQuickGO ontologyBLASTP
333930733404431137spore germination proteinQuickGO ontologyBLASTP
33405233340657135hypothetical proteinBLASTP
334071533441853471hypothetical proteinBLASTP
334415133463432193hypothetical proteinBLASTP