Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:2715623 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27156232716471849hypothetical proteinBLASTP
27201262720692567transcriptional regulator TetR familyQuickGO ontologyBLASTP
272096227221191158acetyltransferase GNAT familyQuickGO ontologyBLASTP
2722305272359412903-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
272361127247471137prephenate dehydrogenaseQuickGO ontologyBLASTP
272470427258041101putative aminotransferaseQuickGO ontologyBLASTP
272582327269951173chorismate synthaseQuickGO ontologyBLASTP
2727118272721699hypothetical proteinBLASTP
2727280272835610773-deoxy-7-phosphoheptulonate synthaseQuickGO ontologyBLASTP
272918827317372550hypothetical proteinBLASTP
27317812732698918hypothetical proteinBLASTP
27328482733285438hypothetical proteinBLASTP
27334342733964531isochorismatase family proteinQuickGO ontologyBLASTP
27339812734514534acetyltransferase GNAT familyQuickGO ontologyBLASTP
27345342734833300hypothetical proteinBLASTP
27349352735450516hypothetical proteinBLASTP
273550227368241323hypothetical proteinBLASTP
27370112737118108hypothetical protein
27371622738160999hypothetical proteinBLASTP
27381502738692543RNA polymerase sigma-70 factorQuickGO ontologyBLASTP