Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:1522937 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1522937153799015054conserved repeat domain proteinQuickGO ontologyBLASTP
15381131538973861acetyltransferase GNAT familyQuickGO ontologyBLASTP
15390141539574561isochorismatase family proteinQuickGO ontologyBLASTP
15397561540016261hypothetical proteinBLASTP
15400191540930912transporter EamA familyQuickGO ontologyBLASTP
15409381541324387ribonuclease HQuickGO ontologyBLASTP
15413941542266873lacX protein putativeQuickGO ontologyBLASTP
15424501542935486hypothetical proteinBLASTP
15431211543738618hypothetical proteinBLASTP
15437511543927177hypothetical proteinBLASTP
15439611544209249hypothetical proteinBLASTP
15443291544526198cold shock protein CspBQuickGO ontologyBLASTP
15447891545517729hypothetical proteinBLASTP
15456571546289633hypothetical proteinBLASTP
15463091546602294hypothetical proteinBLASTP
15466821547311630fatty acid hydroxylase-like proteinQuickGO ontologyBLASTP
15475351547876342hypothetical proteinBLASTP
154787915494291551sodiumsolute symporter family proteinQuickGO ontologyBLASTP