Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:1334000 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
133507613364191344potassium uptake protein TrkH familyQuickGO ontologyBLASTP
13364531336824372hypothetical proteinBLASTP
13371111337518408hypothetical proteinBLASTP
13376031337716114hypothetical proteinBLASTP
13380691338317249hypothetical proteinBLASTP
13384351338674240hypothetical proteinBLASTP
13387341338970237hypothetical proteinBLASTP
13390901339986897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
134030213420021701acetolactate synthase large subunitQuickGO ontologyBLASTP
13419991342508510acetolactate synthase III small subunitQuickGO ontologyBLASTP
134253513435451011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
1343547134506715212-isopropylmalate synthaseQuickGO ontologyBLASTP
1345145134620910653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
134620913476031395isopropylmalate isomerase large subunitQuickGO ontologyBLASTP
13475811348162582isopropylmalate isomerase small subunitQuickGO ontologyBLASTP
134847313497351263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
13497111350346636ATP phosphoribosyltransferaseQuickGO ontologyBLASTP
135035813516471290histidinol dehydrogenaseQuickGO ontologyBLASTP
13516471352231585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
13522321352861630imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
135283413535537201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
13535471354305759imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
135495313559691017histidinol-phosphataseQuickGO ontologyBLASTP
13560371356204168hypothetical proteinBLASTP