Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:8613848 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
86138488614045198hypothetical protein
86141518614369219hypothetical protein
86143848614620237secreted oxidoreductaseQuickGO ontologyBLASTP
861484586160501206secreted oxidoreductaseQuickGO ontologyBLASTP
861604786172761230secreted oxidoreductaseQuickGO ontologyBLASTP
86175668617886321hypothetical protein
86179438618245303hypothetical protein
86183138618951639TetR-family transcriptional regulatorQuickGO ontologyBLASTP
86189748619171198transposaseQuickGO ontologyBLASTP
86194108620069660hypothetical proteinBLASTP
86200888620228141transposase fragmentQuickGO ontology
86203398620857519transposaseQuickGO ontologyBLASTP
86207768621255480transposaseQuickGO ontologyBLASTP
86212858621500216hypothetical proteinBLASTP
86215208621900381hypothetical protein
86232308624186957insertion element transposaseQuickGO ontologyBLASTP
86251988625431234hypothetical proteinBLASTP
86255118625846336hypothetical protein
86263388627069732DNA-binding proteinQuickGO ontologyBLASTP
86270778627355279hypothetical protein
86273588627651294hypothetical proteinBLASTP
86283568628988633TetR-family transcriptional regulatorQuickGO ontologyBLASTP
86290408629804765oxidoreductaseQuickGO ontologyBLASTP
86300508630430381membrane proteinQuickGO ontology
86304278631386960insertion element transposaseQuickGO ontologyBLASTP
86315578632408852hypothetical proteinBLASTP