Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:8594500 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
85950048595444441transcriptional regulatorQuickGO ontologyBLASTP
85955288596418891hypothetical proteinBLASTP
85965838597410828DNA-binding proteinQuickGO ontologyBLASTP
85975408597980441hypothetical proteinBLASTP
85979808598822843hypothetical proteinBLASTP
85988308599405576hypothetical proteinBLASTP
86002978600881585hypothetical protein
86012848601808525hypothetical proteinBLASTP
86025438603184642secreted proteinQuickGO ontologyBLASTP
86031818603747567secreted proteinQuickGO ontologyBLASTP
86043338604653321hypothetical proteinBLASTP
86047118605640930hydrolaseQuickGO ontologyBLASTP
86057978606564768transcriptional regulatorQuickGO ontologyBLASTP
86066718607405735oxidoreductaseQuickGO ontologyBLASTP
86075398608480942transcriptional regulatorQuickGO ontologyBLASTP
860913086103471218probable IS110 transposaseQuickGO ontologyBLASTP
86108518611627777oxidoreductaseQuickGO ontologyBLASTP
86116438612263621transcriptional regulatorQuickGO ontologyBLASTP
86124988613085588hypothetical proteinBLASTP
86134738613841369hypothetical proteinBLASTP