Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:8569962 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
85699628570174213hypothetical protein
857020985724702262integral membrane proteinQuickGO ontologyBLASTP
85731408573652513hypothetical protein
85739198574302384hypothetical proteinBLASTP
85743648575071708hydrolaseQuickGO ontologyBLASTP
85754388575674237hypothetical proteinBLASTP
857630885773721065bifunctional proteinQuickGO ontologyBLASTP
85774038577879477MarR-family transcriptional regulatorQuickGO ontologyBLASTP
85780008578485486hypothetical protein
85790438579414372insertion element transposaseQuickGO ontologyBLASTP
858005685812341179hypothetical proteinBLASTP
858140685831091704hypothetical proteinBLASTP
858310685842001095hypothetical proteinBLASTP
85841978584610414hypothetical protein
85846618585167507regulatory proteinQuickGO ontologyBLASTP
85854638586017555integral membrane proteinQuickGO ontologyBLASTP
85861088586500393hypothetical proteinBLASTP
85865928586975384anti-sigma factor antagonistQuickGO ontologyBLASTP
85871338587375243hypothetical protein
85873968587620225hypothetical protein