Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:7866148 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
786614878682982151integral membrane proteinQuickGO ontologyBLASTP
78686837869120438insertion element transposase fragmentQuickGO ontologyBLASTP
78696837870519837insertion element transposaseQuickGO ontologyBLASTP
787073478719211188phospholipaseQuickGO ontologyBLASTP
78720437872507465hypothetical proteinBLASTP
78726977872801105insertion element transposase fragmentQuickGO ontology
78728347872977144hypothetical protein
78731677873427261hypothetical protein
78736007873947348MerR-family transcriptional regulatorQuickGO ontologyBLASTP
78739707874908939oxidoreductaseQuickGO ontologyBLASTP
78753747876051678two-component system response regulatorQuickGO ontologyBLASTP
787604878772411194probable two-component system sensor kinaseQuickGO ontologyBLASTP
787733578795812247integral membrane proteinQuickGO ontologyBLASTP
78798647880010147hypothetical protein
78802287881130903secreted proteinQuickGO ontology
788184178846392799transcriptional regulatorQuickGO ontologyBLASTP
788475178859621212flavohemoproteinQuickGO ontologyBLASTP
78861267887082957hydrolaseQuickGO ontologyBLASTP
78873217887665345membrane proteinQuickGO ontology
78876947888284591MarR-family regulatory proteinQuickGO ontologyBLASTP
78885777889113537hypothetical protein
78892667890168903RNA polymerase sigma factorQuickGO ontologyBLASTP