Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:7337453 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
733745373388831431secreted proteinQuickGO ontologyBLASTP
73388767339205330hypothetical protein
73392697339949681hypothetical protein
73399837340813831dehydrogenaseQuickGO ontologyBLASTP
73409457341376432hypothetical proteinBLASTP
734163373429071275hypothetical proteinBLASTP
734314273450281887ATPGTP binding proteinQuickGO ontologyBLASTP
734506173472562196ATPGTP binding proteinQuickGO ontologyBLASTP
73473127347440129hypothetical protein
73476557348320666hypothetical protein
734853773532104674protein kinaseQuickGO ontologyBLASTP
735320773568393633hypothetical proteinBLASTP
73567667357356591hypothetical proteinBLASTP
73575197358352834hypothetical proteinBLASTP
73583497358552204hypothetical proteinBLASTP
73588147359689876hypothetical proteinBLASTP
73598657360494630hypothetical protein
736049973624091911transcriptional regulatorQuickGO ontologyBLASTP
73624587362646189hypothetical protein
736294373668273885bacteriophage phiC31 resistance gene pglYQuickGO ontologyBLASTP
736682473697482925bacteriophage phiC31 resistance gene pglZQuickGO ontologyBLASTP
736981773708691053hypothetical proteinBLASTP
737086673726831818hypothetical proteinBLASTP
737285973742081350ATPGTP binding proteinQuickGO ontologyBLASTP
737420873764032196ATP-dependent helicaseQuickGO ontologyBLASTP